Can 1000 mg of Ibuprofen kill you?

Can 1000 mg of ibuprofen kill you? Have you ever thought about it? Nowadays the use of ibuprofen has become very common. People use it without a prescription from doctors. But excess use of ibuprofen can cause many adverse effects. Continue reading this article to know more about ibuprofen.

What is Ibuprofen?

Ibuprofen is an efficient pain reliever, but it can have dangerous negative effects if used in excess. This is true both for long as well as short time. Ibuprofen is an anti-inflammatory, non-steroid medication. Ibuprofen is a drug that is used to relieve pain, fever, and inflammation. It is one of the most widely used medicines on the planet.

Ibuprofen, like any other drug, can be harmful to your health if taken in greater than prescribed doses. Ibuprofen abuse can harm your digestive system, disrupt your hormones, and raise your risk of heart attack and stroke. Ibuprofen overdose can be fatal in some situations.

Accidental ibuprofen poisoning affects both adults and children at alarming rates: the American Association of Poison Control Centres (AAPCC) handled more than 2.7 million poison cases in the United States alone in 2016.

Can 1000 mg of ibuprofen kill you
Fig 1: Chemical structure of ibuprofen

Why is Ibuprofen taken?

Ibuprofen is a nonsteroidal anti-inflammatory medicine (NSAID) that can be purchased over-the-counter to treat inflammation, fever, and mild pain.

This medicine is used for treating the following conditions:

  • headaches
  • backache
  • toothaches
  • menstruation cramps 
  • arthritis
  • fevers

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What is the Prescribed dose?

The amount of ibuprofen you should take is determined by your age.

Dosage of medicine should be decided strictly as per the prescription given by the doctor. It is requested not to follow this dosage without the clinician’s supervision or guidance.

For Adults only

One or two 200-milligram (mg) tablets every 4 to 6 hours is the suggested dosage for adults. Adults should not take more than 800 mg in one sitting or 3,200 mg per day.

To treat their symptoms, adults over the age of 60 should take as little ibuprofen as feasible. Kidney and gastrointestinal side effects are more common in older people.

For Children

To figure out how much ibuprofen to give a child, you’ll need to know the child’s weight and the ibuprofen formulation you’re using. Ibuprofen for children is available in the following form

  • liquid chewable tablets for infants
  • Milliliters are used to measure liquids (mL). Make sure you read the label and take accurate measurements.

In no case should your child receive more than four doses in a single day? Ibuprofen should always be used at the lowest effective dose. In the following timeframes, a single dose should be taken

  • Adults should take medicine on the difference of every 4–6 hours, while children should take a break every 6–8 hours.
  • A greater maximum daily dosage may be prescribed by some doctors.

The recommended and maximum daily dosages in milligrams (mg) and milligrams per kilogram (mg/kg) of body weight for adults and children are summarized in the table below.

Weight50-mg/1.25-mL infant dose100-mg/5-mL liquid dose50-mg/1 chewable tablet dose
12-17 pounds1.25 mL (50 mg)Take the advice of the doctorTake the advice of the doctor
18-23 pounds1.875 mL (75 mg)Take the advice of the doctorTake the advice of the doctor
24-35 pounds2.5 mL (100 mg)5 mL (100 mg)2 tablets (100 mg)
36-47 pounds3.75 mL (150 mg)7.5 mL (150 mg)3 tablets (150 mg)
48-59 pounds5 mL (200 mg)10 mL (200 mg)4 tablets (200 mg)
60-71 poundsn/a12.5 mL (250 mg)5 tablets (250 mg)
72-95 poundsn/a15 mL (300 mg)tablets (300 mg)
>95 poundsn/a20 mL (400 mg)8 tablets (400 mg)
Table 1: Dose for adults as per weight

For infants

Ibuprofen should not be given to children under the age of six months.

The safe dose of the infant formulation for infants aged 6 months to one year is determined by their weight.

Weight50-mg/1.25-mL infant drops dosage
<12 poundsTake the advice of the doctor before administration of the medicine
12 – 17 pounds1.25 mL (50 mg)
18 – 23 pounds1.875 mL (75 mg)
Table 2: Dose of infants and children

Mechanism of Action

Ibuprofen acts by preventing prostaglandin synthesis. When an injury occurs, prostaglandins play an important role in inflammation. They induce flushing of the skin, as well as heat, swelling, and pain. Ibuprofen works by interacting with the COX-1 and COX-2 receptors on prostaglandin synthase, a type of enzyme.

Tablet, caplet, liquid gel, chewable tablet, and liquid suspension or drop forms of ibuprofen are available. It’s also found in a variety of goods, including cold and allergy medications. Lower-strength ibuprofen can be purchased over-the-counter, whereas higher-strength ibuprofen requires a prescription.

Ibuprofen is a safe drug for both children and adults when used at the recommended dosage. Pain relievers are the most commonly overdosed drug class among adults.

Can 1000 mg of ibuprofen kill you
Fig2: Ibuprofen tablets

Ibuprofen Overdose Symptoms

Ibuprofen overdose symptoms do not appear in everyone immediately away. Some individuals will show no signs or symptoms at all. The symptoms of an ibuprofen overdose are usually modest. Mild signs and symptoms may include:

  • tinnitus (ringing ears)
  • heartburn
  • nausea
  • vomiting
  • stomach ache
  • diarrhea
  • dizziness
  • blurred vision
  • rash
  • sweating

More complex symptoms can include:

  • difficult or slow breathing
  • convulsions
  • hypotension (low blood pressure)
  • seizures
  • little to no urine production
  • severe headache
  • coma
Can 1000 mg of ibuprofen kill you
Fig 3: Symptoms of liver disorder due to overdose of medicine

Can 1000 mg of Ibuprofen kill you? Side effects of Ibuprofen overdose

  • changes in vision
  • shortness of breath;
  • Organ swelling or rapid weight gain
  • Mild or severe skin rash
  • Stomach bleeding- Bloody or tarry stools, coughing up blood, or vomit that looks like coffee grounds are all indicators of stomach bleeding.
  • Liver disorders- Nausea, upper stomach pain, itching, tiredness, flu-like symptoms, loss of appetite, dark urine, clay-colored feces, and jaundice (yellowing of the skin or eyes) are all signs of liver disorders.
  • Anemia – RBC low, pale skin, dizziness or shortness of breath, racing heart, difficulty concentrating;
  • Renal problems- Infrequent or no urination, painful or difficult urination, swelling of the feet or ankles, fatigue, or shortness of breath.
Overdose of Ibuprofen can harm kidneys- Can 1000 mg of ibuprofen kill you
Fig 4: Overdose of Ibuprofen can harm kidneys


You should be able to recover from an ibuprofen overdose if you seek medical help right away. However, some people experience problems with their liver, kidneys, or stomach. NSAIDs like ibuprofen should not be taken by people who have had ulcers or gastrointestinal bleeding in the past.

What happens if you take three ibuprofen in 24 hours?

It can sometimes result in bleeding. You could get around that by taking 400 mg three times a day. That is the maximum effect against pain. When it comes to Ibuprofen, less is more.

Ibuprofen stays in your system for how long?

Ibuprofen might take up to 24 hours to completely leave your system, even though its effects usually last 4 to 6 hours. The half-life of around ibuprofen is two hours, according to the prescribed guidelines.

Is it true that ibuprofen can harm your heart?

Ibuprofen, such as Advil, Motrin, or Ibuprofen, might exacerbate current hypertension (high blood pressure) or promote the onset of new hypertension. It can also cause kidney damage (nephrotoxicity), heart failure worsening, and potentially a heart attack or stroke.

Who should avoid ibuprofen?

If you have a history of a strong, unpleasant reaction (hypersensitivity) to aspirin or other NSAIDs, you should avoid taking ibuprofen. have a current or recent stomach ulcer, or have previously had one have serious heart failure

Is there a blood thinner in ibuprofen?

Yes, the pain reliever ibuprofen (Advil) is a blood thinner. It doesn’t literally “thin” your blood, but it does slow down the time it takes for it to clot. It may take longer to create a blood clot if you cut yourself or have an accident that causes bleeding.

What if you take ibuprofen daily?

While you can use ibuprofen for a few days, unless your doctor has prescribed it, it is not recommended that you take it daily to ease the pain. Ibuprofen and other pain relievers can irritate your stomach lining, causing everything from mild nausea to ulcers.

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